By Astrid Sigel, Roland K. O. Sigel
Those sulfur-rich chelators, being vital in steel ion homeostasis, locate expanding consciousness. MILS-5, written through 30 across the world famous specialists, makes a speciality of this sizzling subject. The reader is supported by means of approximately 20 tables, greater than eighty illustrations and approximately 2000 references. This booklet is an important source for scientists operating in quite a lot of disciplines from environmental toxicology and inorganic biochemistry all through to body structure and medication.
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Extra resources for Metallothioneins and Related Chelators (Volume 5) (Metal Ions in Life Sciences)
As the transport of cadmium to the kidney is dependent on its metallothionein binding in plasma, the distribution of cadmium within the body found after an acute exposure will be different from that found after repeated exposures. Figure 1 summarizes the transport of Cd in blood and its uptake in kidney tubules. Met. Ions Life Sci. 2009, 5, 1–29 HISTORICAL DEVELOPMENT AND OVERVIEW 13 Basolateral membrane Brush border Liver cell Plasma Tubular fluid Renal tubular cell Receptor Alb? Damage Cd-Alb Cd MT Cd-MT Cd-MT Cd-MT Urine NAG, Ca, Mg, Proteins Lysosomes Cd-MT Cd MT Cd-MT Glomerular membrane Figure 1.
Ions Life Sci. 2009, 5, 1–29 12 – – – – – M. NORDBERG and G. F. NORDBERG free radical scavenging storage of metal ions metabolism of essential metal ions immune response genotoxicity and carcinogenicity The mechanisms by which MT protects cells from toxicity include binding of metals to proteins and localization in the cell where MT is mainly present in the cytoplasm, but also in the nucleus and in the lysosomes of the kidney. MT stands for detoxification! The protection against adverse effects caused by cadmium exposure follows from the ratio of non-MT-bound to MTbound cadmium .
4. D. P. Maliuga, Doklady Akad. Nauk. 1. 894, Translation RJ–296. 5. J. H. R. Ka¨gi and B. L. Vallee, Biochemistry, 1960, 235, 3460–3465. 6. J. H. R. Ka¨gi and B. L. Vallee, Biochemistry, 1961, 236, 2435–2442. 7. G. F. Nordberg, M. Nordberg, M. Piscator and O. , 1972, 126, 491–498. 8. J. H. R. Ka¨gi, 8th Int. Congr. Biochem. Abstract, 1970, 130–131. 9. M. Piscator, Nordisk hygienisk tidskrift, 1964 XLV 76–82 (english summary). 10. G. F. Nordberg, Environ. , 1971, 1, 171–187. 11. M. Nordberg, G.