By F.F. Nord
Advances in Enzymology and comparable parts of Molecular Biology is a seminal sequence within the box of biochemistry, delivering researchers entry to authoritative stories of the newest discoveries in all parts of enzymology and molecular biology. those landmark volumes date again to 1941, supplying an unequalled view of the ancient improvement of enzymology. The sequence bargains researchers the newest figuring out of enzymes, their mechanisms, reactions and evolution, roles in advanced organic strategy, and their program in either the laboratory and undefined. each one quantity within the sequence positive factors contributions by way of major pioneers and investigators within the box from world wide. All articles are conscientiously edited to make sure thoroughness, caliber, and clarity.
With its wide variety of subject matters and lengthy ancient pedigree, Advances in Enzymology and comparable parts of Molecular Biology can be utilized not just by way of scholars and researchers in molecular biology, biochemistry, and enzymology, but additionally by way of any scientist drawn to the invention of an enzyme, its houses, and its functions.
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Extra resources for Advances in Enzymology and Related Areas of Molecular Biology, Volume 2
Attempts to Obtain Growth of Virus without Growth of the Host Iirueger and Northrop (45)in their first coniprchcnsive study of the interrelation of bacterial growth and of virus growth, had reached the conclusion that virus growth is dependent on lmcterial growth. In later work they modified this view to some extent. Krueger and Fong (52) claimed to have obtained virus growth without bacterial growth by adjusting the pH of the medium to 6 and the temperature to 28” C. With B. 5. These 28 MAX D E L B R ~ ~ C K findings were the starting point for Krueger’s experiments which attempted to show the existence of a precursor of the virus in growing bacteria (50).
The virus C’can be obtained as a rare mutant from aging cultures of the lysogenic strain SF/C, just as the virulent mutant was obtained, in the case described by Gratia, from the strain which was lysogenic with respect to the avirulent form. Clearly, these fbdings open up an experimental approach to a wide range of problems. Mutations of the kind described probably occur quite often. Analysis of the conditions which control their appearance would be of value to the general mutation problem. The work of Burnet and Lush seems to show that they offer also a powerful tool for the analysis of the induction of a type of virus immunity which depends upon the introduction of an indigenous virus.
Fruton, J. , Irving, G. , J . B i d . , 138, 231, 243, 249 (1941). 3. Brown, A. , Trans. Chem. , 81, 373 (1902). 4. Brown, H. , and Glendinning, T. , 81, 388 (1902). 5. Cohen, P. , J. Rial. , 136, 565 (1940). 6. , 135, 733 (1940). 7. , and Stock, C. , 125, 771 (1938). 8. , 2. physik. , 39, 194 (1902). 9. , and Dauphinee, J. , J . Riol. , 85,627 (1930). 10. I. , Enzymologia, 1, 341 (1937). 1 1 . , J. Am. Chem. , 56, 658 (1934). 12. physiol. , 52,326 (1907). 13. , and Menten, hl. , Riochem. Z .