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By F. Sherwood Taylor

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M.. Leonard. P. and Goldman, SJ. (1996) Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin II. Proc. NaIl. Acad. Sci. 93, 10297-10302. Herwig. S. and Strauss, M. (1997) The retinoblastoma protein: a master regulator of cell cycle. differentiation and aqpoptosis, Eur. J Biochem. 246. 581-60 I. e. and Lawlor. PW. (1997) Production of conditionally immortalised cell lines from a transgenic mouse, Audiol. Neuroolol. 2,25-35.

Cell cultures, although they appear innately non-hazardous, also represent potential hazards to laboratory workers. The central issue is that animal cell cultures may carry viruses, and possibly support their growth. Cell and tissue culture procedures have not been commonly associated with infections in laboratory workers, but there have been rare cases of serious laboratory acquired infections and even death through manipulation of animal tissues and cells (McCray, 1986; Lloyd and Jones, 1984; Gregg, 1975).

AD .. Godowski, P. and Ashkenazi, A (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors, Science 277, 818-821. Steel. G. (1977)Terrninology in the description of drug-radiation interactions. Int. J. Radait. Oncol. BioI. Phys. 5, 1145-1150. Wilbur, D. , Camacho. S .. Hilliard. A .. Dill. L.. M. (1992) Chemotherapy if non-small cell lung carcinoma guided by an in vitro drug resistance assay measuring total tumour cell kill, Br. J. Cancer 65,27-32 Wilson, AP. (1992) Cytotoxicity and viability assays.

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