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By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme

Traditionally, rules governing chemical use have frequently inquisitive about widespread chemical substances and acute human healthiness results of publicity to them, in addition to their power to reason melanoma and different adversarial well-being results. As clinical wisdom has improved there was an elevated understanding of the mechanisms wherein chemical compounds may well exert damaging results on human well-being, in addition to their results on other  Read more...

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For example, the protocol includes life cycle assessment and risk assessment as two separate steps, noting that they are not always necessary or appropriate for selecting an alternative (OECD 2013a). The protocol calls for applying Life Cycle Thinking to identify concerns related to potential substitutes’ life cycle and exposure. SPECIFIC FRAMEWORKS CONSIDERED BY THE COMMITTEE California’s Alternatives Analysis program joins alternatives assessment to a decision process for selecting a course of action intended to decrease toxic threats (Kuczenski et al.

GreenScreen® was developed by Clean Production Action, an organization developing tools and strategies in the green chemical space. GreenScreen® is a tool for “benchmarking9” the data on chemicals’ ecotoxicity and human health hazard data. ” Specific hazard and assessment criteria are defined for each of these benchmarks, as described in Chapter 8. Classification (or benchmarking) tools provide threshold values for toxicological end points of interest, for evaluating data about effects of chemicals.

Frameworks: BizNGO, CA SCP, DfE, German Guide, IC2, Lowell, REACH, TURI, UNEP, and UCLA MCDA All the frameworks include some preparatory work before beginning the technical portion of an assessment. The 2009 NRC report, Science and Decisions: Advancing Risk Assessment, also recommends scoping and problem formulation. Scoping is a discussion between decision makers and stakeholders in which assessors have a supporting role, and problem formulation is a discussion between decision makers and assessors (and technically-oriented stakeholders) to develop a detailed technical plan for the assessment that reflects the broad conceptual design developed in the scoping stage.

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